This conference addresses the challenges of vaccination among patients aged 65 and older, a population particularly vulnerable to infectious complications. It proposes a new approach to vaccination based on changes in immunity with age, recent data on vaccine efficacy, and the adaptation of prevention strategies. The session will cover the clinical and organizational benefits of optimized vaccination coverage, as well as the role of community healthcare professionals in identifying, informing, and supporting older patients. Through a practical and up-to-date approach, this presentation aims to strengthen prevention, improve vaccination adherence, and contribute to maintaining seniors’ independence and quality of life.